Table 1

Hypothesis


Animal models in toxicology and disease research.
Correct use of animal models in areas such as basic research.

Assumptions
Usual plus animal models are predictive.
Usual, e.g. there are universal laws.
Hypothesis
X leads to Y.
None or X leads to Y.
Animal test
In an animal test, X led to Y.
X leads to Y based on results in animals.
Hypothesis

X leads to Y in humans.
Test

Apply X in humans and see if it leads to Y or study populations where X was applied and ascertain result.
Conclusion
Since in animals X did/did not lead to Y, X will/will not lead to Y in humans also.
Actual results from humans.

Shanks et al. Philosophy, Ethics, and Humanities in Medicine 2009 4:2   doi:10.1186/1747-5341-4-2